RAB42: A Prognostic Marker Associated with Tumor Immune Microenvironment in Bladder Cancer

نویسندگان

چکیده

RAB42, member rat sarcoma oncogene family was proved to play a key role in cancer-promoting progression. However, its function the progression of bladder cancer still uncertain. We explored and pan-cancer using bioinformatics analysis, including expression, prognostic, genetic alteration, functional pathways, tumor microenvironment drug resistance. Our results indicated that expression increased most cancers, generally poorer patient prognosis. In addition, positively associated with immune cells, such as tumor-associated macrophages Tregs. Elevated predicted resistance several anti-tumor drugs. summary, our study showed is potential prognostic marker pan-cancer. immunosuppressive microenvironment.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluating the Expression of Oct4 as a Prognostic Tumor Marker in Bladder Cancer

Objective(s)The key transcriptional regulator Oct4 is one of the self-renewal and differentiation-related factors in cancer stem cells, where it maintains "stemness" state. Cancer stem cells have been identified in a variety of solid malignancies. They are a small population of tumor cells with stem cell characteristics, which are a likely cause of relapse in cancer patients. Due to high incide...

متن کامل

Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?

Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...

متن کامل

MicroRNAs as biomarkers associated with bladder cancer

Bladder cancer is the fifth most common cancer with significant morbidity and mortality. Recently, numerous studies demonstrated that microRNAs are emerging as diagnostic biomarkers for bladder cancer. Specific miRNA profiles have been identified for several samples from patients with bladder cancer. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles...

متن کامل

Evaluating the Expression of Oct4 as a Prognostic Tumor Marker in Bladder Cancer

OBJECTIVES The key transcriptional regulator Oct4 is one of the self-renewal and differentiation-related factors in cancer stem cells, where it maintains "stemness" state. Cancer stem cells have been identified in a variety of solid malignancies. They are a small population of tumor cells with stem cell characteristics, which are a likely cause of relapse in cancer patients. Due to high inciden...

متن کامل

Rs401681 polymorphism in TERT-CLPTM1L was associated with bladder cancer risk: A meta-analysis

Objective(s):Genome-wide association studies have identified a number of genetic variants of telomerase reverse transcriptase (TERT), cleft lip and palate transmembrane1-like (CLPTM1L) associated with the risk of bladder cancer. Rs401681 polymorphism in TERT-CLPTM1L was of special interest for bladder cancer risk, whereas the results were inconclusive. Materials and Methods:Publications illustr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Indian Journal of Pharmaceutical Sciences

سال: 2023

ISSN: ['0250-474X', '1998-3743']

DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.634